Poor association between dihydropyrimidine dehydrogenase (DPYD) genotype and fluoropyrimidine‐induced toxicity in an Asian population

Abstract Objective Dihydropyrimidine dehydrogenase (DPYD) genotype is closely associated with fluoropyrimidine (FP)‐induced toxicities in Caucasian population and European Medicines Agency now recommends DPYD genotype‐based FP dosing strategy. Patients and Methods The current study aimed to investig...

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Autors principals:	Masashi Kanai, Takahisa Kawaguchi, Masahito Kotaka, Dai Manaka, Junichi Hasegawa, Akinori Takagane, Yoshinori Munemoto, Takeshi Kato, Tetsuya Eto, Tetsuo Touyama, Takanori Matsui, Katsunori Shinozaki, Shigemi Matsumoto, Tsunekazu Mizushima, Masaki Mori, Junichi Sakamoto, Atsushi Ohtsu, Takayuki Yoshino, Shigetoyo Saji, Fumihiko Matsuda
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2023-04-01
Col·lecció:	Cancer Medicine
Matèries:	Asian population DPYD fluoropyrimidine genotyping toxicity
Accés en línia:	https://doi.org/10.1002/cam4.5541
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