M2 Muscarinic Receptor-Dependent Contractions of Airway Smooth Muscle are Inhibited by Activation of β-Adrenoceptors

Abstract Beta-adrenoceptor (β-AR) agonists inhibit cholinergic contractions of airway smooth muscle (ASM), but the underlying mechanisms are unclear. ASM cells express M3 and M2 muscarinic receptors, but the bronchoconstrictor effects of acetylcholine are believed to result from activation of M3Rs,...

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Detalhes bibliográficos

Principais autores:	Tuleen Alkawadri, Pei Yee Wong, Zhihui Fong, Fionnuala T Lundy, Lorcan P McGarvey, Mark A Hollywood, Keith D Thornbury, Gerard P Sergeant
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Physiological Society 2022-01-01
coleção:	Function
Assuntos:	airways cholinergic COPD smooth muscle muscarinic bronchodilation
Acesso em linha:	https://journals.physiology.org/doi/10.1093/function/zqac050
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