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M2 Muscarinic Receptor-Dependent Contractions of Airway Smooth Muscle are Inhibited by Activation of β-Adrenoceptors

Abstract Beta-adrenoceptor (β-AR) agonists inhibit cholinergic contractions of airway smooth muscle (ASM), but the underlying mechanisms are unclear. ASM cells express M3 and M2 muscarinic receptors, but the bronchoconstrictor effects of acetylcholine are believed to result from activation of M3Rs,...

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Autori principali: Tuleen Alkawadri, Pei Yee Wong, Zhihui Fong, Fionnuala T Lundy, Lorcan P McGarvey, Mark A Hollywood, Keith D Thornbury, Gerard P Sergeant
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2022-01-01
Serie:Function
Soggetti:
airways
cholinergic
COPD
smooth muscle
muscarinic
bronchodilation
Accesso online:https://journals.physiology.org/doi/10.1093/function/zqac050
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