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M2 Muscarinic Receptor-Dependent Contractions of Airway Smooth Muscle are Inhibited by Activation of β-Adrenoceptors

Abstract Beta-adrenoceptor (β-AR) agonists inhibit cholinergic contractions of airway smooth muscle (ASM), but the underlying mechanisms are unclear. ASM cells express M3 and M2 muscarinic receptors, but the bronchoconstrictor effects of acetylcholine are believed to result from activation of M3Rs,...

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Hlavní autoři: Tuleen Alkawadri, Pei Yee Wong, Zhihui Fong, Fionnuala T Lundy, Lorcan P McGarvey, Mark A Hollywood, Keith D Thornbury, Gerard P Sergeant
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2022-01-01
Edice:Function
Témata:
airways
cholinergic
COPD
smooth muscle
muscarinic
bronchodilation
On-line přístup:https://journals.physiology.org/doi/10.1093/function/zqac050
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