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NAT10-mediated crosstalk between acetylation and PARylation enhances the function of PARP1 promoting primary resistance in esophageal cancer

Abstract Resistance to platinum-based drugs represents a significant challenge in the clinical treatment of esophageal cancer. Particularly, some esophageal cancer patients exhibit primary resistance to platinum-based drugs. Our study revealed that the level of N-acetyltransferase 10 (NAT10) is inve...

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Principais autores: Yake Chen, Sizhen Hou, Boyuan Jiang, Yang Yang, Yisi Fan, Xinyue Huang, Fengxiang Liu, Wenjing An, Qiaocen Geng, Jie Yin, Huiqin Zheng, Kexin Guo, Ting Li, Wenwen Zhao, Zhijian Deng, Di Han, Heng Li, Yu Song
Formato: Artigo
Idioma:Inglês
Publicado em: Springer 2026-05-01
coleção:Cellular and Molecular Life Sciences
Assuntos:
Primary resistance
Esophageal cancer
Acetylation
PARylation
N-acetyltransferase 10
Acesso em linha:https://doi.org/10.1007/s00018-026-06182-5
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