NAT10-mediated crosstalk between acetylation and PARylation enhances the function of PARP1 promoting primary resistance in esophageal cancer

Abstract Resistance to platinum-based drugs represents a significant challenge in the clinical treatment of esophageal cancer. Particularly, some esophageal cancer patients exhibit primary resistance to platinum-based drugs. Our study revealed that the level of N-acetyltransferase 10 (NAT10) is inve...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Yake Chen, Sizhen Hou, Boyuan Jiang, Yang Yang, Yisi Fan, Xinyue Huang, Fengxiang Liu, Wenjing An, Qiaocen Geng, Jie Yin, Huiqin Zheng, Kexin Guo, Ting Li, Wenwen Zhao, Zhijian Deng, Di Han, Heng Li, Yu Song
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Springer 2026-05-01
Цуврал:	Cellular and Molecular Life Sciences
Нөхцлүүд:	Primary resistance Esophageal cancer Acetylation PARylation N-acetyltransferase 10
Онлайн хандалт:	https://doi.org/10.1007/s00018-026-06182-5
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!