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DePARylation is critical for S phase progression and cell survival

Poly(ADP-ribose)ylation or PARylation by PAR polymerase 1 (PARP1) and dePARylation by poly(ADP-ribose) glycohydrolase (PARG) are equally important for the dynamic regulation of DNA damage response. PARG, the most active dePARylation enzyme, is recruited to sites of DNA damage via pADPr-dependent and...

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Principais autores: Litong Nie, Chao Wang, Min Huang, Xiaoguang Liu, Xu Feng, Mengfan Tang, Siting Li, Qinglei Hang, Hongqi Teng, Xi Shen, Li Ma, Boyi Gan, Junjie Chen
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2024-04-01
Serier:eLife
Fag:
PARG
PARP1
ribosylation
PARylation
PARG inhibitor
parp inhibitor
Online adgang:https://elifesciences.org/articles/89303
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