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Correlations between pathogenic variants in DNA repair genes and anticancer treatment efficacy in stage IV non‐small cell lung cancer: A large real‐world cohort and review of the literature

Abstract Background Mutations in genes involved in DNA damage repair (DDR), a hallmark of cancer, are associated with increased cancer cell sensitivity to certain therapies. This study sought to evaluate the association of DDR pathogenic variants with treatment efficacy in patients with advanced non...

Deskribapen osoa

Gorde:
Egile Nagusiak: Itamar Averbuch, Roi Tschernichovsky, Oded Icht, Daniel A. Goldstein, Raz Mutai, Elizabeth Dudnik, Ofer Rotem, Nir Peled, Aaron M. Allen, Smadar Laufer‐Geva, Yael Goldberg, Alona Zer
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Wiley 2023-06-01
Saila:Thoracic Cancer
Gaiak:
DNA damage repair mutations
immunotherapy
non‐small cell lung cancer
platinum‐based chemotherapy
radiotherapy
Sarrera elektronikoa:https://doi.org/10.1111/1759-7714.14902
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