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Defucosylated Mouse–Dog Chimeric Anti-EGFR Antibody Exerts Antitumor Activities in Mouse Xenograft Models of Canine Tumors

The epidermal growth factor receptor (EGFR) contributes to tumor malignancy via gene amplification and protein overexpression. Previously, we developed an anti-human EGFR (hEGFR) monoclonal antibody, namely EMab-134, which detects hEGFR and dog EGFR (dEGFR) with high sensitivity and specificity. In...

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Autori principali: Guanjie Li, Tomokazu Ohishi, Mika K. Kaneko, Junko Takei, Takuya Mizuno, Manabu Kawada, Masaki Saito, Hiroyuki Suzuki, Yukinari Kato
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2021-12-01
Serie:Cells
Soggetti:
EGFR
mouse–dog chimeric antibody
ADCC
CDC
canine osteosarcoma
antitumor activity
Accesso online:https://www.mdpi.com/2073-4409/10/12/3599
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