A Defucosylated Anti-EpCAM Monoclonal Antibody (EpMab-37-mG_2a-f) Exerts Antitumor Activity in Xenograft Model

The epithelial cell adhesion molecule (EpCAM) is a stem cell and carcinoma antigen, which mediates cellular adhesion and proliferative signaling by the proteolytic cleavage. In contrast to low expression in normal epithelium, EpCAM is frequently overexpressed in various carcinomas, which correlates...

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Huvudupphov:	Teizo Asano, Tomohiro Tanaka, Hiroyuki Suzuki, Guanjie Li, Tomokazu Ohishi, Manabu Kawada, Takeo Yoshikawa, Mika K. Kaneko, Yukinari Kato
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	MDPI AG 2022-11-01
Serie:	Antibodies
Ämnen:	EpCAM breast cancer pancreatic cancer antitumor activities antibody-dependent cellular cytotoxicity
Länkar:	https://www.mdpi.com/2073-4468/11/4/74
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