Defucosylated Monoclonal Antibody (H₂Mab-139-mG_2a-f) Exerted Antitumor Activities in Mouse Xenograft Models of Breast Cancers against Human Epidermal Growth Factor Receptor 2

The clinically approved human epidermal growth factor receptor 2 (HER2)-targeting monoclonal antibodies (mAbs), trastuzumab, and pertuzumab, target domains IV and II, respectively. Trastuzumab is now the standard treatment for HER2-overexpressed breast and gastric cancers, and trastuzumab in combina...

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Ngā kaituhi matua:	Hiroyuki Suzuki, Tomokazu Ohishi, Ren Nanamiya, Manabu Kawada, Mika K. Kaneko, Yukinari Kato
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2023-09-01
Rangatū:	Current Issues in Molecular Biology
Ngā marau:	antibody-dependent cellular cytotoxicity breast cancer HER2 monoclonal antibody antitumor activities mouse tumor model
Urunga tuihono:	https://www.mdpi.com/1467-3045/45/10/488
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!