Humanization of the antigen-recognition domain does not impinge on the antigen-binding, cytokine secretion, and antitumor reactivity of humanized nanobody-based CD19-redirected CAR-T cells

Abstract Background The immunogenicity of the antigen-recognition domains of chimeric antigen receptor (CAR)-T cells leads to immune responses that may compromise the antitumor effects of the adoptively transferred T cells. Herein, we attempt to humanize a CD19-specific VHH (named H85) using in sili...

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Hauptverfasser:	Pooria Safarzadeh Kozani, Pouya Safarzadeh Kozani, Fatemeh Rahbarizadeh
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-07-01
Schriftenreihe:	Journal of Translational Medicine
Schlagworte:	Cancer immunotherapy CD19 Nanobody Humanization Chimeric antigen receptor Monoclonal antibody
Online-Zugang:	https://doi.org/10.1186/s12967-024-05461-8
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