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Humanization of the antigen-recognition domain does not impinge on the antigen-binding, cytokine secretion, and antitumor reactivity of humanized nanobody-based CD19-redirected CAR-T cells

Abstract Background The immunogenicity of the antigen-recognition domains of chimeric antigen receptor (CAR)-T cells leads to immune responses that may compromise the antitumor effects of the adoptively transferred T cells. Herein, we attempt to humanize a CD19-specific VHH (named H85) using in sili...

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Autori principali: Pooria Safarzadeh Kozani, Pouya Safarzadeh Kozani, Fatemeh Rahbarizadeh
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2024-07-01
Serie:Journal of Translational Medicine
Soggetti:
Cancer immunotherapy
CD19
Nanobody
Humanization
Chimeric antigen receptor
Monoclonal antibody
Accesso online:https://doi.org/10.1186/s12967-024-05461-8
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