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Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression

Abstract Immune checkpoint therapy, where CD8 tumor infiltrating T lymphocytes (TIL) are reactivated, is a promising anti‐cancer treatment approach, yet with low response rates. The extracellular matrix, in particular tenascin‐C, may generate barriers for TIL. To investigate this possibility, we use...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Devadarssen Murdamoothoo, Zhen Sun, Alev Yilmaz, Gilles Riegel, Chérine Abou‐Faycal, Claire Deligne, Ines Velazquez‐Quesada, William Erne, Marine Nascimento, Matthias Mörgelin, Gérard Cremel, Nicodème Paul, Raphael Carapito, Romain Veber, Hélène Dumortier, Jingping Yuan, Kim S Midwood, Thomas Loustau, Gertraud Orend
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Nature 2021-05-01
Schriftenreihe:EMBO Molecular Medicine
Schlagworte:
CD8 tumor infiltrating lymphocytes
CXCL12
extracellular matrix
tenascin‐C
Tumor immune microenvironment
Online-Zugang:https://doi.org/10.15252/emmm.202013270
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