Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression

Abstract Immune checkpoint therapy, where CD8 tumor infiltrating T lymphocytes (TIL) are reactivated, is a promising anti‐cancer treatment approach, yet with low response rates. The extracellular matrix, in particular tenascin‐C, may generate barriers for TIL. To investigate this possibility, we use...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Devadarssen Murdamoothoo, Zhen Sun, Alev Yilmaz, Gilles Riegel, Chérine Abou‐Faycal, Claire Deligne, Ines Velazquez‐Quesada, William Erne, Marine Nascimento, Matthias Mörgelin, Gérard Cremel, Nicodème Paul, Raphael Carapito, Romain Veber, Hélène Dumortier, Jingping Yuan, Kim S Midwood, Thomas Loustau, Gertraud Orend
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Springer Nature 2021-05-01
سلاسل:	EMBO Molecular Medicine
الموضوعات:	CD8 tumor infiltrating lymphocytes CXCL12 extracellular matrix tenascin‐C Tumor immune microenvironment
الوصول للمادة أونلاين:	https://doi.org/10.15252/emmm.202013270
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!