The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells

Abstract Background Triptans are anti-migraine drugs with a potential central site of action. However, it is not known to what extent triptans cross the blood–brain barrier (BBB). The aim of this study was therefore to determine if triptans pass the brain capillary endothelium and investigate the po...

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Bibliografische gegevens

Hoofdauteurs:	Nana Svane, Alberte Bay Villekjær Pedersen, Anne Rodenberg, Burak Ozgür, Lasse Saaby, Christoffer Bundgaard, Mie Kristensen, Peer Tfelt-Hansen, Birger Brodin
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	BMC 2024-05-01
Reeks:	Fluids and Barriers of the CNS
Onderwerpen:	Blood–brain barrier Capillary endothelium Triptans Migraine treatment Proton-coupled organic cation antiporter P-glycoprotein
Online toegang:	https://doi.org/10.1186/s12987-024-00544-6
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