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The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells

Abstract Background Triptans are anti-migraine drugs with a potential central site of action. However, it is not known to what extent triptans cross the blood–brain barrier (BBB). The aim of this study was therefore to determine if triptans pass the brain capillary endothelium and investigate the po...

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Principais autores: Nana Svane, Alberte Bay Villekjær Pedersen, Anne Rodenberg, Burak Ozgür, Lasse Saaby, Christoffer Bundgaard, Mie Kristensen, Peer Tfelt-Hansen, Birger Brodin
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-05-01
Serier:Fluids and Barriers of the CNS
Fag:
Blood–brain barrier
Capillary endothelium
Triptans
Migraine treatment
Proton-coupled organic cation antiporter
P-glycoprotein
Online adgang:https://doi.org/10.1186/s12987-024-00544-6
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