Comparative analysis of the uptake of the H+/OC antiporter substrate oxycodone across and into brain endothelial and parenchymal cells with in vitro–in vivo extrapolation

Abstract Background In vitro evaluation of substances utilizing the putative proton‑coupled organic cation (H+/OC) antiporter for active uptake across the blood-brain barrier (BBB) and brain cell membranes requires a thorough understanding of cellular pharmacokinetics supported by reliable translati...

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主要な著者:	Frida Bällgren, Nana Svane, Aghavni Ginosyan, Alberte Bay Villekjaer Pedersen, Shannuo Li, Jessica Mahajan, Morten Schallburg Nielsen, Birger Brodin, Irena Loryan
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2025-10-01
シリーズ:	Fluids and Barriers of the CNS
主題:	Putative proton-coupled organic cation (H+/OC) antiporter Oxycodone Pyrilamine hCMEC/D3 Primary brain endothelial cells Brain slice
オンライン･アクセス:	https://doi.org/10.1186/s12987-025-00726-w
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