Identification of WDR62 variants as a genetic contributor for human infertility

WDR62 is crucial for the initiation of germ cell meiosis in mice. In Wdr62-deficient male mice, germ cells are arrested at the metaphase I stage of meiosis due to asymmetric centrosome distribution and abnormal spindle assembly. In our study, two homozygous WDR62 variants (c .375C > G [Tyr125Ter] an...

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Principais autores:	Mohan Liu, Gan Shen, Jun Ma, Xue Yang, Chanjuan Zhao, Li Duan, Liangchai Zhuo, Guicheng Zhao, Chuan Jiang, Erpo Tian, Dingming Li, Ying Shen
Format:	Artigo
Sprog:	Inglês
Udgivet:	KeAi Communications Co., Ltd. 2025-09-01
Serier:	Cell Investigation
Fag:	Male infertility Oligoasthenoteratozoospermia WDR62 Acrosome development Flagella genesis
Online adgang:	http://www.sciencedirect.com/science/article/pii/S3050538025000195
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