Microcephaly-associated protein WDR62 supports purine metabolism by interacting with co-chaperone BAG2

Abstract Inherited mutations in the spindle pole-associated scaffold protein WDR62 cause autosomal recessive primary microcephaly. Previous research has characterised the roles of WDR62 in the regulation of spindle dynamics, cell division, and brain development. Here, we identify a new function of t...

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Үндсэн зохиолчид:	Matthew J Morris, Yvonne Y Yeap, Jonathon R Edwards, Chi Chen, Annalisa Paolino, Sebastian G B Furness, S Sean Millard, Julia K Pagan, Laura R Fenlon, Dominic C H Ng
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Springer Nature 2026-03-01
Цуврал:	The EMBO Journal
Нөхцлүүд:	BAG2 Microcephaly Molecular Chaperones Purine Metabolism WDR62
Онлайн хандалт:	https://doi.org/10.1038/s44318-026-00724-0
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!