Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth

The second most commonly mutated gene in primary microcephaly (MCPH) patients is wd40-repeat protein 62 (wdr62), but the relative contribution of WDR62 function to the growth of major brain lineages is unknown. Here, we use Drosophila models to dissect lineage-specific WDR62 function(s). Interesting...

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Principais autores:	Nicholas R. Lim, Belal Shohayeb, Olga Zaytseva, Naomi Mitchell, S. Sean Millard, Dominic C.H. Ng, Leonie M. Quinn
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2017-07-01
coleção:	Stem Cell Reports
Assuntos:	neuroblast glia WD-repeat protein WDR62 AURKA mitosis Drosophila brain microcephaly
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2213671117302229
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