CpxA Phosphatase Inhibitor Activates CpxRA and Is a Potential Treatment for Uropathogenic Escherichia coli in a Murine Model of Infection

ABSTRACT CpxRA is an envelope stress response system that is highly conserved in the Enterobacteriaceae. CpxA has kinase activity for CpxR and phosphatase activity for phospho-CpxR (CpxR-P), a transcription factor. In response to membrane stress, CpxR-P is produced and upregulates genes involved in...

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Detalhes bibliográficos

Principais autores:	Kate R. Fortney, Sara N. Smith, Julia J. van Rensburg, Julie A. Brothwell, Jessi J. Gardner, Barry P. Katz, Nagib Ahsan, Adam S. Duerfeldt, Harry L. T. Mobley, Stanley M. Spinola
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2022-04-01
coleção:	Microbiology Spectrum
Assuntos:	Escherichia coli UPEC CpxRA phosphatase inhibitor treatment
Acesso em linha:	https://journals.asm.org/doi/10.1128/spectrum.02430-21
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