CpxA Phosphatase Inhibitor Activates CpxRA and Is a Potential Treatment for Uropathogenic Escherichia coli in a Murine Model of Infection

ABSTRACT CpxRA is an envelope stress response system that is highly conserved in the Enterobacteriaceae. CpxA has kinase activity for CpxR and phosphatase activity for phospho-CpxR (CpxR-P), a transcription factor. In response to membrane stress, CpxR-P is produced and upregulates genes involved in...

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Главные авторы:	Kate R. Fortney, Sara N. Smith, Julia J. van Rensburg, Julie A. Brothwell, Jessi J. Gardner, Barry P. Katz, Nagib Ahsan, Adam S. Duerfeldt, Harry L. T. Mobley, Stanley M. Spinola
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology 2022-04-01
Серии:	Microbiology Spectrum
Предметы:	Escherichia coli UPEC CpxRA phosphatase inhibitor treatment
Online-ссылка:	https://journals.asm.org/doi/10.1128/spectrum.02430-21
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