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CpxA Phosphatase Inhibitor Activates CpxRA and Is a Potential Treatment for Uropathogenic Escherichia coli in a Murine Model of Infection

ABSTRACT CpxRA is an envelope stress response system that is highly conserved in the Enterobacteriaceae. CpxA has kinase activity for CpxR and phosphatase activity for phospho-CpxR (CpxR-P), a transcription factor. In response to membrane stress, CpxR-P is produced and upregulates genes involved in...

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Main Authors: Kate R. Fortney, Sara N. Smith, Julia J. van Rensburg, Julie A. Brothwell, Jessi J. Gardner, Barry P. Katz, Nagib Ahsan, Adam S. Duerfeldt, Harry L. T. Mobley, Stanley M. Spinola
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2022-04-01
Series:Microbiology Spectrum
Subjects:
Escherichia coli
UPEC
CpxRA
phosphatase inhibitor
treatment
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02430-21
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