Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch

Post-translational control of PERIOD stability by Casein Kinase 1δ and ε (CK1) plays a key regulatory role in metazoan circadian rhythms. Despite the deep evolutionary conservation of CK1 in eukaryotes, little is known about its regulation and the factors that influence substrate selectivity on func...

Full description

Bibliographic Details

Main Authors:	Jonathan M Philpott, Rajesh Narasimamurthy, Clarisse G Ricci, Alfred M Freeberg, Sabrina R Hunt, Lauren E Yee, Rebecca S Pelofsky, Sarvind Tripathi, David M Virshup, Carrie L Partch
Format:	Artigo
Language:	Inglês
Published:	eLife Sciences Publications Ltd 2020-02-01
Series:	eLife
Subjects:	in vitro biochemistry human cell culture mouse cell culture protiens
Online Access:	https://elifesciences.org/articles/52343
Tags:	Add Tag No Tags, Be the first to tag this record!