Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch

Post-translational control of PERIOD stability by Casein Kinase 1δ and ε (CK1) plays a key regulatory role in metazoan circadian rhythms. Despite the deep evolutionary conservation of CK1 in eukaryotes, little is known about its regulation and the factors that influence substrate selectivity on func...

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Hlavní autoři:	Jonathan M Philpott, Rajesh Narasimamurthy, Clarisse G Ricci, Alfred M Freeberg, Sabrina R Hunt, Lauren E Yee, Rebecca S Pelofsky, Sarvind Tripathi, David M Virshup, Carrie L Partch
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	eLife Sciences Publications Ltd 2020-02-01
Edice:	eLife
Témata:	in vitro biochemistry human cell culture mouse cell culture protiens
On-line přístup:	https://elifesciences.org/articles/52343
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