A Reproducible Sequence-Level Strategy to Enhance Peptide Immunogenicity While Preserving Wild-Type Epitope Recognition

<b>Background:</b> Short peptide epitopes are valuable for mechanistic studies, yet their intrinsic low immunogenicity and lack of commercial antibodies hinder rapid antibody generation. <b>Methods:</b> We developed a reproducible, sequence-level workflow combining cross-species/structural triage, i...

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Hlavní autoři:	Chia-Hung Chen, Yu-Chi Chiu, Kai-Yao Huang, Hsiao-Hsuan Huang, Ta-Wei Kuo, Yu-Chi Liu, Hui-Ju Kao, Chen-Lin Yu, Shun-Long Weng, Kuang-Wen Liao
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2025-12-01
Edice:	Antibodies
Témata:	peptide immunogenicity sequence-level antigen engineering conservative (heteroclitic) mutagenesis cross-reactive antibodies
On-line přístup:	https://www.mdpi.com/2073-4468/14/4/106
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