A Reproducible Sequence-Level Strategy to Enhance Peptide Immunogenicity While Preserving Wild-Type Epitope Recognition

<b>Background:</b> Short peptide epitopes are valuable for mechanistic studies, yet their intrinsic low immunogenicity and lack of commercial antibodies hinder rapid antibody generation. <b>Methods:</b> We developed a reproducible, sequence-level workflow combining cross-species/structural triage, i...

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Autori principali:	Chia-Hung Chen, Yu-Chi Chiu, Kai-Yao Huang, Hsiao-Hsuan Huang, Ta-Wei Kuo, Yu-Chi Liu, Hui-Ju Kao, Chen-Lin Yu, Shun-Long Weng, Kuang-Wen Liao
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2025-12-01
Serie:	Antibodies
Soggetti:	peptide immunogenicity sequence-level antigen engineering conservative (heteroclitic) mutagenesis cross-reactive antibodies
Accesso online:	https://www.mdpi.com/2073-4468/14/4/106
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