Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense

Obligate intracellular Chlamydia trachomatis replicate in a membrane-bound vacuole called inclusion, which serves as a signaling interface with the host cell. Here, we show that the chlamydial deubiquitinating enzyme (Cdu) 1 localizes in the inclusion membrane and faces the cytosol with the active d...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Annette Fischer, Kelly S Harrison, Yesid Ramirez, Daniela Auer, Suvagata Roy Chowdhury, Bhupesh K Prusty, Florian Sauer, Zoe Dimond, Caroline Kisker, P Scott Hefty, Thomas Rudel
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	eLife Sciences Publications Ltd 2017-03-01
Schriftenreihe:	eLife
Schlagworte:	Chlamydia trachomatis deubiquitinase Mcl-1 cell-autonomous defense
Online-Zugang:	https://elifesciences.org/articles/21465
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