Nuclear translocation of MLKL enhances necroptosis by a RIP1/RIP3-independent mechanism in H9c2 cardiomyoblasts

Accumulating evidence suggests that necroptosis of cardiomyocytes contributes to cardiovascular diseases. Lethal disruption of the plasma membrane in necroptosis is induced by oligomers of mixed lineage kinase domain-like (MLKL) that is translocated to the membrane from the cytosol. However, the rol...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Shoya Ino, Toshiyuki Yano, Atsushi Kuno, Masaya Tanno, Hidemichi Kouzu, Tatsuya Sato, Tomohisa Yamashita, Wataru Ohwada, Arata Osanami, Toshifumi Ogawa, Yuki Toda, Masaki Shimizu, Tetsuji Miura
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-02-01
Colecção:	Journal of Pharmacological Sciences
Assuntos:	Necroptosis Cardiomyocyte MLKL RIP1 RIP3
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1347861322000974
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!