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Telomerase reverse transcriptase gene amplification in hematological malignancies

Abstract Background Telomere is a complex DNA–protein structure located at the end of all eukaryotic chromosomes. The major role of human telomerase is to catalyze the addition of telomeric repeat sequences TTAGGG onto chromosome ends for stabilization of telomere length in attaining cellular immort...

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Autori principali: Amany H. Abdelrahman, Maha M. Eid, Mirhane Hassan, Ola M. Eid, Rania M. A. AbdelKader, Nevin M. AlAzhary, Rasha Y. Shahin, Mohamed T. Sallam
Natura: Artigo
Lingua:Inglês
Pubblicazione: SpringerOpen 2019-11-01
Serie:Egyptian Journal of Medical Human Genetics
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Accesso online:https://doi.org/10.1186/s43042-019-0036-z
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