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Systematic Comparison of CRISPR and shRNA Screens to Identify Essential Genes Using a Graph-Based Unsupervised Learning Model

Generally, essential genes identified using shRNA and CRISPR are not always the same, raising questions about the choice between these two screening platforms. To address this, we systematically compared the performance of CRISPR and shRNA to identify essential genes across different gene expression...

Ful tanımlama

Kaydedildi:
Asıl Yazarlar: Yulian Ding, Connor Denomy, Andrew Freywald, Yi Pan, Franco J. Vizeacoumar, Frederick S. Vizeacoumar, Fang-Xiang Wu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI AG 2024-10-01
Seri Bilgileri:Cells
Konular:
CRISPR
shRNA
gene expression
essential gene
graph-based model
consensus maximization
Online Erişim:https://www.mdpi.com/2073-4409/13/19/1653
Etiketler: Etiketle
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