Solid Organ Transplantation Is Associated with an Increased Rate of Mismatch Repair Deficiency and PIK3CA Mutations in Colorectal Cancer

Solid organ transplants are associated with a modestly increased risk of colorectal cancers (CRC). However, the molecular profile of these cancers has not been described. We hypothesized that transplant-related immunosuppression may promote development of more immunogenic tumors as suggested by a hi...

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Autors principals:	Eric S. Christenson, Valerie Lee, Hao Wang, Mark Yarchoan, Ana De Jesus-Acosta, Nilo Azad, Ahmet Gurakar, Ming-Tseh Lin, Dung T. Le, Daniel C. Brennan, Elizabeth M. Jaffee, Katherine Bever
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2022-12-01
Col·lecció:	Current Oncology
Matèries:	mismatch repair deficient colon cancer PIK3CA mutations calcineurin Inhibitors post-transplant malignancies high tumor mutation burden tumors immune surveillance
Accés en línia:	https://www.mdpi.com/1718-7729/30/1/6
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