Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons

Huntington's Disease is a neurodegenerative condition caused by a polyglutamine expansion in the huntingtin (Htt) protein, which aggregates and also causes neuronal dysfunction. Pathogenic N-terminal htt fragments perturb axonal transport in vitro. To determine whether this occurs in vivo and to elu...

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Autors principals:	C. Sinadinos, T. Burbidge-King, D. Soh, L.M. Thompson, J.L. Marsh, A. Wyttenbach, A.K. Mudher
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2009-05-01
Col·lecció:	Neurobiology of Disease
Matèries:	Huntington's Disease N-terminal huntingtin Drosophila Motor neurons Axonal transport neuropeptide-Y
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S0969996109000424
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