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8OHdG as a marker for Huntington disease progression

Leukocyte 8-hydroxydeoxyguanosine (8OHdG) is an indicator of oxidative stress, impaired metabolism, and mitochondrial dysfunction, features that have been implicated in Huntington disease (HD). Increased levels of 8OHdG have been reported in the caudate, parietal cortex, and peripherally in the seru...

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Principais autores: Jeffrey D. Long, Wayne R. Matson, Andrew R. Juhl, Blair R. Leavitt, Jane S. Paulsen
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2012-06-01
Serier:Neurobiology of Disease
Fag:
8OHdG
Huntington disease
Biomarker
Oxidative stress
Mitochondrial dysfunction
PREDICT-HD
Online adgang:http://www.sciencedirect.com/science/article/pii/S0969996112000678
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