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Radix Paeoniae Alba attenuates Radix Bupleuri-induced hepatotoxicity by modulating gut microbiota to alleviate the inhibition of saikosaponins on glutathione synthetase

Radix Bupleuri (RB) is commonly used to treat depression, but it can also lead to hepatotoxicity after long-term use. In many anti-depression prescriptions, RB is often used in combination with Radix Paeoniae Alba (RPA) as an herb pair. However, whether RPA can alleviate RB-induced hepatotoxicity re...

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Principais autores: Congcong Chen, Wenxia Gong, Junshen Tian, Xiaoxia Gao, Xuemei Qin, Guanhua Du, Yuzhi Zhou
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2023-06-01
coleção:Journal of Pharmaceutical Analysis
Assuntos:
Radix Bupleuri
Radix Paeoniae Alba
Hepatotoxicity
Gut microbiota
Saikosaponins
Combination mechanisms
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2095177923000837
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