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Radix Paeoniae Alba attenuates Radix Bupleuri-induced hepatotoxicity by modulating gut microbiota to alleviate the inhibition of saikosaponins on glutathione synthetase

Radix Bupleuri (RB) is commonly used to treat depression, but it can also lead to hepatotoxicity after long-term use. In many anti-depression prescriptions, RB is often used in combination with Radix Paeoniae Alba (RPA) as an herb pair. However, whether RPA can alleviate RB-induced hepatotoxicity re...

Deskribapen osoa

Gorde:
Egile Nagusiak: Congcong Chen, Wenxia Gong, Junshen Tian, Xiaoxia Gao, Xuemei Qin, Guanhua Du, Yuzhi Zhou
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2023-06-01
Saila:Journal of Pharmaceutical Analysis
Gaiak:
Radix Bupleuri
Radix Paeoniae Alba
Hepatotoxicity
Gut microbiota
Saikosaponins
Combination mechanisms
Sarrera elektronikoa:http://www.sciencedirect.com/science/article/pii/S2095177923000837
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