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Targeting RNA-binding protein HuR to inhibit the progression of renal tubular fibrosis

Abstract Background Upregulation of an RNA-binding protein HuR has been implicated in glomerular diseases. Herein, we evaluated whether it is involved in renal tubular fibrosis. Methods HuR was firstly examined in human kidney biopsy tissue with tubular disease. Second, its expression and the effect...

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Main Authors: Zhimin Huang, Simeng Liu, Anna Tang, Xiaoqing Wu, Jeffrey Aube, Liang Xu, Yufeng Huang
Format: Artigo
Language:Inglês
Published: BMC 2023-06-01
Series:Journal of Translational Medicine
Subjects:
RNA-binding protein
HuR inhibitor
Ischemia–reperfusion
Renal fibrosis
Chronic kidney disease
Online Access:https://doi.org/10.1186/s12967-023-04298-x
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