Nuclear PKM2: a signal receiver, a gene programmer, and a metabolic modulator

Abstract Pyruvate kinase M2 (PKM2) is a key enzyme involved in glycolysis, yet its role in cancer extends far beyond metabolic flux. Unlike its isoform PKM1, PKM2 exhibits unique regulatory properties due to alternative splicing and dynamic structural plasticity, enabling it to translocate into the...

Полное описание

Библиографические подробности

Главные авторы:	Tsan-Jan Chen, Chun-Hsien Wu, Mien-Chie Hung, Wen-Ching Wang, Hsing-Jien Kung
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2025-08-01
Серии:	Journal of Biomedical Science
Предметы:	Nuclear PKM2 Nuclear translocation Post-translational modification Oncogenic signaling Cancer metabolism Signal receiver
Online-ссылка:	https://doi.org/10.1186/s12929-025-01170-6
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