Nuclear PKM2: a signal receiver, a gene programmer, and a metabolic modulator

Abstract Pyruvate kinase M2 (PKM2) is a key enzyme involved in glycolysis, yet its role in cancer extends far beyond metabolic flux. Unlike its isoform PKM1, PKM2 exhibits unique regulatory properties due to alternative splicing and dynamic structural plasticity, enabling it to translocate into the...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Tsan-Jan Chen, Chun-Hsien Wu, Mien-Chie Hung, Wen-Ching Wang, Hsing-Jien Kung
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2025-08-01
Цуврал:	Journal of Biomedical Science
Нөхцлүүд:	Nuclear PKM2 Nuclear translocation Post-translational modification Oncogenic signaling Cancer metabolism Signal receiver
Онлайн хандалт:	https://doi.org/10.1186/s12929-025-01170-6
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!