HBV-Induced Pyruvate Increases Lactylation of Pyruvate Kinase M2 (PKM2) at K206 to Promote Liver Fibrosis

We previously demonstrated that HBV promotes liver fibrosis through the enhanced production of pyruvate. Pyruvate kinase M2 (PKM2), a key enzyme in pyruvate metabolism, plays an important role in liver fibrogenesis. Recently, lactylation of PKM2 has been identified, which contributes to stabilize it...

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Váldodahkkit:	Wenxian Wen, Qin Du, Shuhan Li, Youmin Yang, Xianding Wang, Shasha Li, Yujia Li, Shilin Li, Chunhui Yang, He Xie, Xiaoqiong Duan, Limin Chen
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	MDPI AG 2026-04-01
Ráidu:	Pathogens
Fáttát:	hepatitis B virus pyruvate liver fibrosis PKM2 lactylation
Liŋkkat:	https://www.mdpi.com/2076-0817/15/4/431
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