Integrative network analysis of miRNA-mRNA expression profiles during epileptogenesis in rats reveals therapeutic targets after emergence of first spontaneous seizure

Abstract Epileptogenesis is the process by which a normal brain becomes hyperexcitable and capable of generating spontaneous recurrent seizures. The extensive dysregulation of gene expression associated with epileptogenesis is shaped, in part, by microRNAs (miRNAs) – short, non-coding RNAs that nega...

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Autors principals:	Niraj Khemka, Gareth Morris, Laleh Kazemzadeh, Lara S. Costard, Valentin Neubert, Sebastian Bauer, Felix Rosenow, Morten T. Venø, Jørgen Kjems, David C. Henshall, Jochen H. M. Prehn, Niamh M. C. Connolly
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2024-07-01
Col·lecció:	Scientific Reports
Matèries:	Epilepsy Epileptogensis microRNA miRNA-mRNA interactions Bayesian modelling Temporal expression profiling
Accés en línia:	https://doi.org/10.1038/s41598-024-66117-7
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