Integrative network analysis of miRNA-mRNA expression profiles during epileptogenesis in rats reveals therapeutic targets after emergence of first spontaneous seizure

Abstract Epileptogenesis is the process by which a normal brain becomes hyperexcitable and capable of generating spontaneous recurrent seizures. The extensive dysregulation of gene expression associated with epileptogenesis is shaped, in part, by microRNAs (miRNAs) – short, non-coding RNAs that nega...

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Detalhes bibliográficos

Principais autores:	Niraj Khemka, Gareth Morris, Laleh Kazemzadeh, Lara S. Costard, Valentin Neubert, Sebastian Bauer, Felix Rosenow, Morten T. Venø, Jørgen Kjems, David C. Henshall, Jochen H. M. Prehn, Niamh M. C. Connolly
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-07-01
coleção:	Scientific Reports
Assuntos:	Epilepsy Epileptogensis microRNA miRNA-mRNA interactions Bayesian modelling Temporal expression profiling
Acesso em linha:	https://doi.org/10.1038/s41598-024-66117-7
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