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E3 Ubiquitin Ligases in Neurological Diseases: Focus on Gigaxonin and Autophagy

Ubiquitination is a dynamic post-translational modification that regulates the fate of proteins and therefore modulates a myriad of cellular functions. At the last step of this sophisticated enzymatic cascade, E3 ubiquitin ligases selectively direct ubiquitin attachment to specific substrates. Altog...

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Bibliografiske detaljer
Principais autores: Léa Lescouzères, Pascale Bomont
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-10-01
Serier:Frontiers in Physiology
Fag:
Online adgang:https://www.frontiersin.org/articles/10.3389/fphys.2020.01022/full
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