The Kelch 3 motif on gigaxonin mediates the interaction with NUDCD3 and regulates vimentin filament morphology

Gigaxonin is an intermediate filament (IF)-interacting partner belonging to the Kelch-like (KLHL) protein family. Gigaxonin is encoded by the KLHL16 gene, which is mutated in Giant Axonal Neuropathy (GAN). The lack of functional gigaxonin in GAN patient cells impairs IF proteostasis by affecting IF...

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Үндсэн зохиолчид:	Cassandra L. Phillips, Christina So, Meredith F. Gillis, Jonathan Harrison, Chih-Hsuan Hsu, Diane Armao, Natasha T. Snider
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2025-09-01
Цуврал:	European Journal of Cell Biology
Нөхцлүүд:	Gigaxonin Kelch domain Intermediate filaments Cytoskeleton Chaperone NUDCD3
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S0171933525000330
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!