Impaired airway epithelial miR-155/BACH1/NRF2 axis and hypoxia gene expression during RSV infection in children with down syndrome

BackgroundChildren with Down Syndrome (DS) are at high risk for severe respiratory syncytial virus (RSV) infections. DS is associated with impaired cellular responses to oxidative stress and hypoxia; however, these abnormalities have not been explored in trisomy 21 (TS21) airway epithelial cells (AE...

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Autors principals:	Allison Welham, Elizabeth Chorvinsky, Surajit Bhattacharya, Kyle Salka, Betelehem Solomon Bera, Woudasie Admasu, Maria C. Straker, Maria J. Gutierrez, Jyoti K. Jaiswal, Gustavo Nino
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-05-01
Col·lecció:	Frontiers in Pediatrics
Matèries:	trisomy 21 (Down syndrome) RSV (respiratory syncytial virus) airway epithelia miR-155 hypoxia
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fped.2025.1553571/full
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