Impaired airway epithelial miR-155/BACH1/NRF2 axis and hypoxia gene expression during RSV infection in children with down syndrome

BackgroundChildren with Down Syndrome (DS) are at high risk for severe respiratory syncytial virus (RSV) infections. DS is associated with impaired cellular responses to oxidative stress and hypoxia; however, these abnormalities have not been explored in trisomy 21 (TS21) airway epithelial cells (AE...

Descrición completa

Detalles Bibliográficos

Principais autores:	Allison Welham, Elizabeth Chorvinsky, Surajit Bhattacharya, Kyle Salka, Betelehem Solomon Bera, Woudasie Admasu, Maria C. Straker, Maria J. Gutierrez, Jyoti K. Jaiswal, Gustavo Nino
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2025-05-01
Series:	Frontiers in Pediatrics
Assuntos:	trisomy 21 (Down syndrome) RSV (respiratory syncytial virus) airway epithelia miR-155 hypoxia
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fped.2025.1553571/full
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!