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Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation

The mutant proinsulin syndrome is a monogenic cause of diabetes mellitus due to toxic misfolding of insulin’s biosynthetic precursor. Also designated mutant INS-gene induced diabetes of the young (MIDY), this syndrome defines molecular determinants of foldability in the endoplasmic reticulum (ER) of...

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Furkejuvvon:
Váldodahkkit: Balamurugan Dhayalan, Michael D. Glidden, Alexander N. Zaykov, Yen-Shan Chen, Yanwu Yang, Nelson B. Phillips, Faramarz Ismail-Beigi, Mark A. Jarosinski, Richard D. DiMarchi, Michael A. Weiss
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Frontiers Media S.A. 2022-03-01
Ráidu:Frontiers in Endocrinology
Fáttát:
monogenic diabetes
endoplasmic reticular stress
peptide chemistry
protein folding
oxidative folding intermediate
Liŋkkat:https://www.frontiersin.org/articles/10.3389/fendo.2022.821069/full
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