Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation

The mutant proinsulin syndrome is a monogenic cause of diabetes mellitus due to toxic misfolding of insulin’s biosynthetic precursor. Also designated mutant INS-gene induced diabetes of the young (MIDY), this syndrome defines molecular determinants of foldability in the endoplasmic reticulum (ER) of...

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Bibliografiske detaljer

Principais autores:	Balamurugan Dhayalan, Michael D. Glidden, Alexander N. Zaykov, Yen-Shan Chen, Yanwu Yang, Nelson B. Phillips, Faramarz Ismail-Beigi, Mark A. Jarosinski, Richard D. DiMarchi, Michael A. Weiss
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2022-03-01
Serier:	Frontiers in Endocrinology
Fag:	monogenic diabetes endoplasmic reticular stress peptide chemistry protein folding oxidative folding intermediate
Online adgang:	https://www.frontiersin.org/articles/10.3389/fendo.2022.821069/full
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