Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation

The mutant proinsulin syndrome is a monogenic cause of diabetes mellitus due to toxic misfolding of insulin’s biosynthetic precursor. Also designated mutant INS-gene induced diabetes of the young (MIDY), this syndrome defines molecular determinants of foldability in the endoplasmic reticulum (ER) of...

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מידע ביבליוגרפי

Principais autores:	Balamurugan Dhayalan, Michael D. Glidden, Alexander N. Zaykov, Yen-Shan Chen, Yanwu Yang, Nelson B. Phillips, Faramarz Ismail-Beigi, Mark A. Jarosinski, Richard D. DiMarchi, Michael A. Weiss
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2022-03-01
סדרה:	Frontiers in Endocrinology
נושאים:	monogenic diabetes endoplasmic reticular stress peptide chemistry protein folding oxidative folding intermediate
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fendo.2022.821069/full
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!